What is pah?

Pulmonary arterial hypertension (PAH) (WHO Group 1) is high blood pressure in the arteries of the lungs. The increased pressure affects the ability of the heart and lungs to work properly.

Here is how blood vessels in the lungs function normally, compared with those affected by PAH

In healthy lungs, blood vessels are wide enough so blood can flow through them freely.

Healthy vessel

Blood vessels in the lungs are wide enough so blood can flow through them freely.

With PAH, blood vessels in the lungs narrow, making it difficult for blood to flow through them.

Vessel with PAH

Blood vessels in the lungs narrow, making it difficult for blood to flow through them.

See how PAH affects blood vessels

With PAH, there is an imbalance of 3 natural substances in the body

In patients with PAH, there is an imbalance in 3 substances that normally help keep blood vessels in your lungs open:

Nitric oxide and pah

Too little nitric oxide

Learn more about nitric oxide

Nitric oxide does many different things in the body, including helping control blood pressure by opening arteries (also known as dilation) when needed.

Endothelin and pah

Too much endothelin

Learn more about endothelin

Endothelin increases blood pressure and narrows blood vessels.

Prostacyclin and pah

Too little prostacyclin

Learn more about prostacyclin

Prostacyclin works in different ways within healthy blood vessels. It helps with dilation and it helps prevent the vessels from getting blocked.

When working properly, each of these substances works in its own way to help blood flow freely through your blood vessels.


What happens when these substances are out of balance?

When these substances are out of balance, blood vessels in the lungs will narrow, and the heart has to work harder to pump blood to the lungs to get oxygen that is needed by the rest of the body.

This causes the symptoms of PAH.

Currently, there is no medical test to determine if 1, 2, or all 3 substances are out of balance.

Talk to your doctor about the medicines you are taking and whether you can do more to correct the imbalance.


Learn more about United Therapeutics treprostinil treatment options

Learn more about United Therapeutics medicines

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Treatment options for adult patients with pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs.

  • ORENITRAM is a prescription medication shown to delay the progression of PAH and improve your ability to exercise.

  • TYVASO is a prescription medicine that can improve your ability to exercise.

  • REMODULIN is a prescription medicine that can reduce symptoms associated with exercise. In patients who need to switch from epoprostenol, REMODULIN is approved to slow the worsening of symptoms.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

IMPORTANT SAFETY INFORMATION FOR ORENITRAM

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

EXPAND FOR MORE carrot Img

Treatment options for adult patients with pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs.

  • ORENITRAM is a prescription medication shown to delay the progression of PAH and improve your ability to exercise.

  • TYVASO is a prescription medicine that can improve your ability to exercise.

  • REMODULIN is a prescription medicine that can reduce symptoms associated with exercise. In patients who need to switch from epoprostenol, REMODULIN is approved to slow the worsening of symptoms.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

IMPORTANT SAFETY INFORMATION FOR ORENITRAM

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.